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In Crohn's disease and ulcerative colitis, inflammation blocks its own healing

Medical Xpress1 min read74 words
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Researchers from institutions in Kiel, Germany, and the United States have identified a biological mechanism that explains why inflammation persists in Crohn’s disease and ulcerative colitis despite the body’s natural regulatory efforts. The study reveals that chronic intestinal inflammation directly interferes with a critical metabolic pathway responsible for delivering energy to the cells lining the gut. This disruption prevents the intestinal barrier from properly repairing itself, allowing inflammatory processes to continue unchecked.

Under normal

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